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Last Updated: April 26, 2024

Details for Patent: 7,727,994

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Summary for Patent: 7,727,994

Title:	Methods of treating patients suffering from movement disorders
Abstract:	The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A.sub.2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A.sub.2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A.sub.2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson's disease by administering an adenosine A.sub.2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.
Inventor(s):	Kase; Hiroshi (Tokyo, JP), Mori; Akihisa (Chiba, JP), Waki; Yutaka (Princeton, NJ), Ohsawa; Yutaka (London, GB), Karasawa; Akira (Shizuoka, JP), Kuwana; Yoshihisa (Shizuoka, JP)
Assignee:	Kyowa Hakko Kirin Co., Ltd. (Tokyo, JP)
Application Number:	11/326,516
Patent Claim Types: see list of patent claims	Use;

Drugs Protected by US Patent 7,727,994

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Australia	2003207734	⤷ Try a Trial
Australia	2008200611	⤷ Try a Trial
Brazil	0306919	⤷ Try a Trial
Canada	2473864	⤷ Try a Trial
Canada	2813048	⤷ Try a Trial
China	101543497	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration	>Supplementary Protection Certificate	>SPC Country	>SPC Expiration

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