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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
Argus Health
McKesson
Medtronic
Johnson and Johnson
Baxter
Harvard Business School
Dow
Accenture

Generated: June 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 7,652,069

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Which drugs does patent 7,652,069 protect, and when does it expire?

Patent 7,652,069 protects ZOLINZA and is included in one NDA.

This patent has eighty-six patent family members in twenty-eight countries.
Summary for Patent: 7,652,069
Title:Polymorphs of suberoylanilide hydroxamic acid
Abstract:The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo. The present invention also provides a novel Form I polymorph of SAHA, characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well a unique crystalline structure.
Inventor(s): Miller; Thomas A. (Brookline, MA), Richon; Victoria M. (Wellesley, MA)
Assignee: Merck HDAC Research, LLC (Boston, MA)
Application Number:11/981,367
Patent Claim Types:
see list of patent claims
Composition; Use; Formulation; Dosage form;

Drugs Protected by US Patent 7,652,069

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Merck ZOLINZA vorinostat CAPSULE;ORAL 021991-001 Oct 6, 2006 RX Yes Yes ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 7,652,069

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
7,456,219 Polymorphs of suberoylanilide hydroxamic acid ➤ Sign Up
7,847,122 Polymorphs of suberoylanilide hydroxamic acid ➤ Sign Up
7,851,509 Polymorphs of suberoylanilide hydroxamic acid ➤ Sign Up
7,148,257 Methods of treating mesothelioma with suberoylanilide hydroxamic acid ➤ Sign Up
Patent No. Title Estimated Patent Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Fish and Richardson
Cipla
Medtronic
Mallinckrodt
Julphar
Teva
McKesson
Colorcon
Healthtrust

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