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Generated: August 22, 2017

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Title:Benzimidazole derivatives, their production and use
Abstract: Benzimidazole derivatives of the formula (I): ##STR00001## wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R.sup.1 is hydrogen or an optionally substituted hydrocarbon residue; R.sup.2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R' is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is --O--, --S(O).sub.m-- or --N(R.sup.4)-- wherein m is an integer of 0, 1 or 2 and R.sup.4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.
Inventor(s): Naka; Takehiko (Higashinada-ku, JP), Nishikawa; Kohei (Nishikyo-ku, JP), Kato; Takeshi (Higashiosaka, JP)
Assignee: Takeda Pharmaceutical Company Limited (Osaka, JP)
Application Number:11/594,982
Patent Claim Types:
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Compound;

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Foreign Priority and PCT Information for Patent: ► Subscribe

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan1990-113148Apr 27, 1990
Japan1990-141942May 30, 1990
Japan1990-208662Aug 06, 1990
Japan1990-264579Oct 01, 1990
Japan1990-413679Dec 24, 1990

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Serving 500+ biopharmaceutical companies globally:

McKinsey
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US Army
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Healthtrust
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