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Generated: April 29, 2017

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Details for Patent: 7,342,005

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Summary for Patent: 7,342,005

Title:Antibiotic compounds
Abstract:The present invention relates to carbapenems and provides a compound of the formula (I): ##STR00001## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R.sup.1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R.sup.2 is hydrogen or C.sub.1-4alkyl; R.sup.3 is hydrogen or C.sub.1-4alkyl; R.sup.4 and R.sup.5 are the same or different and are selected from hydrogen, halo, cyano, C.sub.1-4alkyl, nitro, hydroxy, carboxy, C.sub.1-4alkoxy, C.sub.1-4alkoxycarbonyl, aminosulphonyl, C.sub.1-4alkylaminosulphonyl, di-C.sub.1-4-alkylaminosulphonyl, carbamoyl, C.sub.1-4alkylcarbamoyl, di-C.sub.1-4alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C.sub.1-4alkylamino, di-C.sub.1-4alkylamino, C.sub.1-4alkanoylamino, C.sub.1-4alkanoyl(N--C.sub.1-4alkyl)amino, C.sub.1-4alkanesulphonamido and C.sub.1-4alkylS(O).sub.n--wherein n is zero, one or two; with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the link to --NR.sup.3--; processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.
Inventor(s): Betts; Michael John (Wilmslow, GB), Davies; Gareth Morse (Macclesfield, GB), Swain; Michael Lingard (Stockport, GB)
Assignee: AstraZeneca UK Limited (London, GB)
Application Number:11/126,331
Patent Claim Types:
see list of patent claims
Composition; Formulation; Compound; Process;

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Foreign Priority and PCT Information for Patent: 7,342,005

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9202298.7Feb 04, 1992

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