Details for Patent: 6,869,939
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Summary for Patent: 6,869,939
Title: | Formulations containing amiodarone and sulfoalkyl ether cyclodextrin |
Abstract: | The present invention provides aqueous parenteral formulations containing an antiarrhythmic agent, such as amiodarone, and a sulfoalkyl ether cyclodextrin. The liquid formulations are clear, sterilizable, and chemically and physically stable. The liquid formulations do not require a surfactant and do not precipitate upon dilution with distilled water or other pharmaceutically acceptable liquid carrier. The sulfoalkyl ether cyclodextrin-containing formulation provides significant advantages over other cyclodextrin-containing formulations of amiodarone. The formulation can be prepared in acidic, neutral and slightly basic medium while providing acceptable concentrations of amiodarone suitable for parenteral administration. An SAE-CD-containing formulation of amiodarone can be provided in liquid form or as a reconstitutable powder. Moreover, highly concentrated solutions exceeding 200 mg of amiodarone per mL can be prepared. Solutions can be made either dilutable or non-dilutable with water at room temperature or under conditions typically encountered in the clinic. |
Inventor(s): | Mosher; Gerold L. (Kansas City, MO), Johnson; Karen T. (Lawrence, KS), Gayed; Atef A. (Overland Park, KS) |
Assignee: | CyDex, Inc. (Lenexa, KS) |
Application Number: | 10/139,620 |
Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 6,869,939 |
Patent Claim Types: see list of patent claims | Formulation; Compound; Composition; Use; |
Drugs Protected by US Patent 6,869,939
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International Family Members for US Patent 6,869,939
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Austria | 535239 | ⤷ Try a Trial | |||
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