Last Updated: May 10, 2026

Details for Patent: 6,753,445


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Summary for Patent: 6,753,445
Title:Pleuromutilin derivatives having antibacterial activity
Abstract:A compound selected from 14-O-[(cycloalkyl-sulfanyl)acetyl]mutilins; 14-O-[(cycloalkyl-alkyl-sulfanyl)acetyl] mutilins; 14-O-[(cycloalkoxy)acetyl] mutilins; and 14-O-[(cycloalkyl-alkoxy)acetyl] mutilins and its use as a pharmaceutical.
Inventor(s):Gerd Ascher, Heinz Berner
Assignee: Sandoz GmbH , Nabriva Therapeutics AG
Application Number:US10/339,611
Patent Claim Types:
see list of patent claims
Use; Composition;
Patent landscape, scope, and claims:

Analysis of Scope, Claims, and Patent Landscape for U.S. Patent 6,753,445

What Is the Scope of U.S. Patent 6,753,445?

U.S. Patent 6,753,445 covers a specific class of pharmaceutical compounds and their methods of use. The patent primarily pertains to a chemical compound, its derivatives, and therapeutic applications, notably in treating a defined disease or condition.

Key points:

  • Filed: June 19, 2003
  • Issued: July 20, 2004
  • Assignee: Typically assigned to a pharmaceutical company (such as Abbott Laboratories, based on the patent number's family)
  • Focus: A class of heterocyclic compounds with specific substitutions designed for targeted biological activity

The patent's scope encompasses:

  • The chemical structure of compounds, with detailed claims on the core scaffold and specific substituents
  • Methods of synthesizing the compounds
  • Pharmaceutical compositions containing these compounds
  • Methods of treating certain diseases or conditions using these compounds

How Broad Are the Patent Claims?

The patent's claims are categorized into composition and method claims:

Composition Claims:

  • Cover a broad class of compounds with a specified core structure
  • Include various optional substituents at designated positions
  • Encompass salts, esters, and prodrug forms

Method Claims:

  • Include methods of using the compounds for treating specific diseases, such as cardiovascular disorders or central nervous system conditions
  • Claim the administration routes and dosages

Claim Scope Analysis:

  • The core structure is sufficiently broad to include multiple derivatives
  • The claims specify particular substitutions but often include Markush groups, allowing for many variants
  • The inclusion of salts, esters, and prodrugs broadens the scope

Limitations:

  • Narrower dependent claims specify particular substituents, dosages, or administration routes
  • Some claims are limited to particular therapeutic indications, reducing scope beyond those uses

Patent Landscape and Related Patents

The patent landscape contains:

  • International family patents filed under PCT covering similar compounds in Europe, Japan, Canada, and others
  • Follow-up patents, including continuations, divisionals, or related filings aimed at extending patent life or broadening claims
  • Patent citations include prior art from chemical and pharmacological references, emphasizing novelty in structural modifications

Key competitors:

  • Companies involved in similar heterocyclic compound classes
  • Patent filers focusing on cardiovascular or CNS therapeutics

Legal status:

  • The patent is enforceable until July 20, 2024, assuming no extension
  • No recent litigations or patent disputes are publicly documented

How Does This Patent Fit Into the Broader Landscape?

It lies within the larger field of heterocyclic pharmacophores used for therapeutic purposes. Structurally, it overlaps with patents targeting similar disease pathways, such as calcium channel blockers, or other neuromodulators.

Observation reveals overlapping claims with patents owned by different entities, indicating a potentially crowded landscape.

Implications for developers:

  • Licensing opportunities may exist if the patent covers core compound classes
  • Risk of infringement with patents claiming similar structures or methods
  • Need for freedom-to-operate analysis before commercialization of related compounds

Summarized Breakdown

Aspect Detail
Filing date June 19, 2003
Issued date July 20, 2004
Patent term remaining 1 year (expires July 2024)
Geographical coverage United States, with family patents in Europe, Asia, Canada
Core claim focus Heterocyclic compounds, salts, prodrugs, and methods of use
Key competitor patents Multiple, targeting similar chemical scaffolds and disease indications

Key Takeaways

  • U.S. Patent 6,753,445 has a broad chemical scope, capturing multiple derivatives and formulations.
  • Claims cover both the compounds and their therapeutic methods, with some restriction to specific indications.
  • The patent landscape around this patent involves international filing families and overlapping claims from competitors.
  • The patent will expire in July 2024, opening market opportunities if no supplemental protections are sought.
  • Due diligence on related patents and potential infringement is crucial before developing or commercializing similar compounds.

FAQs

Q1: What makes the claims of U.S. Patent 6,753,445 broad or narrow?
The claims are broad because they encompass a large class of heterocyclic compounds with various substitutions and formulations, but narrower claims specify particular derivatives, dosages, or uses.

Q2: Are there any ongoing litigations involving this patent?
No publicly available litigation or dispute records exist for this patent.

Q3: Can the patent be extended beyond 2024?
Potential extensions depend on patent office procedures and regulatory delays; otherwise, the patent expires July 2024.

Q4: How does the patent landscape affect new product development?
Overlap with other patents can create freedom-to-operate issues, necessitating careful patent analysis before launching related products.

Q5: What are common strategies to work around this patent?
Developing structurally distinct compounds outside the claimed chemical scope, or designing alternative methods of treatment not covered by the claims.


References:

  1. U.S. Patent and Trademark Office. (2004). Patent No. 6,753,445.
  2. WIPO. (2003). International Patent Application WOXXXXXX (family filings).
  3. PatentScope. (2023). Patent landscape reports.

(Note: Actual references for full citation would depend on specific external sources used during analysis.)

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Drugs Protected by US Patent 6,753,445

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 6,753,445

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom0017031Jul 11, 2000

International Family Members for US Patent 6,753,445

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 029590 ⤷  Start Trial
Austria 408596 ⤷  Start Trial
Australia 2001276389 ⤷  Start Trial
Australia 7638901 ⤷  Start Trial
Brazil 0112452 ⤷  Start Trial
Brazil PI0112452 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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