|Title:||Powder formulation disintegrating system and method for dry powder inhalers|
|Abstract:||A disperser for dry powders which can be used with different dose systems, dose weights ranging from 2 to 25 mg and different types of powder formulation. In one embodiment, the disperser acts both as a de-agglomeration (disintegration; aerosolization) means and as an air classifier for especially adhesive mixtures. Only fine drug particles are emitted whereas the larger agglomerates and carrier crystals are retained by the disperser. Another embodiment enables time controlled release of carrier crystals in these mixtures. Yet another embodiment has optimized performance with spherical pellets, containing no carrier crystals. Other possible embodiments of the invention make it possible to control the total inhaler resistance and the powder deposition in the upper respiratory tract by means of the addition of a so-called sheath flow of clean air. Modifications also enable carrier retainment in the mouthpiece and elimination of the tangential flow component of the discharge cloud.|
|Inventor(s):||Haaije de Boer; Anne (Drachten, NL), Frijlink; Henderik Willem (Eelde, NL), Gjaltema; Doetie (Oosterwolde, NL), Goede; Joachim (Hanau, DE), Hagedoorn; Paul (Assen, NL)|
|Assignee:||Sofotec GmbH & Co. KG (Frankfurt am Main, DE)|
Patent Claim Types:|
see list of patent claims
Field: Medical technology
Back Citations: 89th percentile
Forward Citations: 3rd percentile
|Applicant||Tradename||Generic Name||Dosage||NDA||Approval Date||Type||RLD||Patent No.||Patent Expiration||Product||Substance||Delist Req.||Patented / Exclusive Use|
|POWDER, METERED;INHALATION||202450-001||Jul 23, 2012||RX||Yes||6,681,768||► subscribe||Y|
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