Oral pharmaceutical compositions containing long-chain triglycerides and liphophilic surfactants
Abstract:
This invention is directed to pharmaceutical compositions for oral administration, wherein the drug or active ingredient is known to have stability problems associated with the use of free fatty acids. The compositions of the invention enhance the solubility of such compounds and improve the storage stability thereof and can be advantageously used in soft-gel and hard-shell capsular formulations. The liquid pharmaceutical compositions, according to the present invention, have a drug dissolved in a liquid vehicle. The liquid vehicle comprising a glyceride of a long chain fatty acid and a lypophilic surfactant having an HLB of less than ten. The composition, according to the invention, is also substantially free of free fatty acids.
Inventor(s):
Aylwin; Elizabeth Anne (Swindon, GB), Banbury; Susan (Cheltenham, GB), Ferdinando; Josephine Joan Christine (Tadley, GB), de Nijs; Henrik (Oss, NL)
Assignee:
R.P. Scherer Technologies, Inc. (Paradise Valley, NV)
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