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|Title:||Use of borate-polyol complexes in ophthalmic compositions|
|Abstract:||Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the boratepolyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.|
|Inventor(s):||Chowhan; Masood (Arlington, TX), Dassanayake; Nissanke L. (Arlington, TX)|
|Assignee:||Alcon Manufacturing, Ltd. (Fort Worth, TX)|
Patent Claim Types:|
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Back Citations: 38th percentile
Forward Citations: 3rd percentile
|Patent Number||Expiration Date|
|6,503,497||January 07, 2015|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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