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Last Updated: April 24, 2024

Details for Patent: 6,500,456

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Summary for Patent: 6,500,456

Title:	Compressed nitroglycerin tablet and its method of manufacture
Abstract:	The present invention is directed to a stable nitroglycerin containing pharmaceutical composition, preferably a tablet which is prepared by direct compression technology. The formulation closely replicates the properties of nitroglycerin molded sublingual tablets (e.g. adequate disintegration and sublingual absorption), while reducing the problems experienced with compressed tablets (e.g. friability and weight variations). The stable tablets are characterized by a decreased migration of nitroglycerin, decreased potency loss, excellent content uniformity when stored. The preferred combination of components are: nitroglycerin/lactose dilution, hydrous lactose, glyceril monostearate, fumed silica, pregelantinized starch and calcium stearate. The preferred process employs direct compression technology to yield composition showing adequate disintegration, bioavailability and improved stability.
Inventor(s):	Capella; Roberto L. (Landing, NJ)
Assignee:	Warner-Lambert Company (Morris Plains, NJ)
Application Number:	09/508,705
Patent Claim Types: see list of patent claims	Composition; Dosage form; Process;

Drugs Protected by US Patent 6,500,456

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

Foreign Priority and PCT Information for Patent: 6,500,456

PCT Information
PCT Filed	September 16, 1998	PCT Application Number:	PCT/US98/19356
PCT Publication Date:	April 15, 1999	PCT Publication Number:	WO99/17766

International Family Members for US Patent 6,500,456

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	209911	⤷ Try a Trial
Australia	759018	⤷ Try a Trial
Australia	9489398	⤷ Try a Trial
Brazil	9812605	⤷ Try a Trial
Canada	2299231	⤷ Try a Trial
Germany	69802832	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration	>Supplementary Protection Certificate	>SPC Country	>SPC Expiration

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