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Serving leading biopharmaceutical companies globally:

Harvard Business School
Cerilliant
Chubb
Colorcon
Accenture
Cantor Fitzgerald
Covington
Novartis
AstraZeneca
Moodys

Generated: October 19, 2017

DrugPatentWatch Database Preview

Details for Patent: 6,500,456

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Which drugs does patent 6,500,456 protect, and when does it expire?


Patent 6,500,456 protects NITROSTAT and is included in one NDA. There have been two Paragraph IV challenges on Nitrostat.

This patent has thirteen patent family members in fifteen countries.

Summary for Patent: 6,500,456

Title: Compressed nitroglycerin tablet and its method of manufacture
Abstract:The present invention is directed to a stable nitroglycerin containing pharmaceutical composition, preferably a tablet which is prepared by direct compression technology. The formulation closely replicates the properties of nitroglycerin molded sublingual tablets (e.g. adequate disintegration and sublingual absorption), while reducing the problems experienced with compressed tablets (e.g. friability and weight variations). The stable tablets are characterized by a decreased migration of nitroglycerin, decreased potency loss, excellent content uniformity when stored. The preferred combination of components are: nitroglycerin/lactose dilution, hydrous lactose, glyceril monostearate, fumed silica, pregelantinized starch and calcium stearate. The preferred process employs direct compression technology to yield composition showing adequate disintegration, bioavailability and improved stability.
Inventor(s): Capella; Roberto L. (Landing, NJ)
Assignee: Warner-Lambert Company (Morris Plains, NJ)
Application Number:09/508,705
Patent Claim Types:
see list of patent claims
Composition; Dosage form; Process;

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Pfizer Pharms
NITROSTAT
nitroglycerin
TABLET;SUBLINGUAL021134-001May 1, 2000ABRXYesNo► Subscribe► Subscribe
Pfizer Pharms
NITROSTAT
nitroglycerin
TABLET;SUBLINGUAL021134-002May 1, 2000ABRXYesNo► Subscribe► Subscribe
Pfizer Pharms
NITROSTAT
nitroglycerin
TABLET;SUBLINGUAL021134-003May 1, 2000ABRXYesYes► Subscribe► Subscribe
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Foreign Priority and PCT Information for Patent: 6,500,456

PCT Information
PCT FiledSeptember 16, 1998PCT Application Number:PCT/US98/19356
PCT Publication Date:April 15, 1999PCT Publication Number: WO99/17766

International Patent Family for Patent: 6,500,456

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office1019039► Subscribe
Canada2299231► Subscribe
Germany69802832► Subscribe
Denmark1019039► Subscribe
Brazil9812605► Subscribe
Spain2169558► Subscribe
Israel134395► Subscribe
Japan2001518500► Subscribe
New Zealand502878► Subscribe
Portugal1019039► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Covington
McKinsey
Cerilliant
Mallinckrodt
AstraZeneca
Harvard Business School
Chinese Patent Office
McKesson
Express Scripts

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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