Generated: December 17, 2017
DrugPatentWatch Database Preview
Details for Patent: 6,500,456
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Which drugs does patent 6,500,456 protect, and when does it expire?
Summary for Patent: 6,500,456
|Title:|| Compressed nitroglycerin tablet and its method of manufacture|
|Abstract:||The present invention is directed to a stable nitroglycerin containing pharmaceutical composition, preferably a tablet which is prepared by direct compression technology. The formulation closely replicates the properties of nitroglycerin molded sublingual tablets (e.g. adequate disintegration and sublingual absorption), while reducing the problems experienced with compressed tablets (e.g. friability and weight variations). The stable tablets are characterized by a decreased migration of nitroglycerin, decreased potency loss, excellent content uniformity when stored. The preferred combination of components are: nitroglycerin/lactose dilution, hydrous lactose, glyceril monostearate, fumed silica, pregelantinized starch and calcium stearate. The preferred process employs direct compression technology to yield composition showing adequate disintegration, bioavailability and improved stability.|
|Inventor(s):|| Capella; Roberto L. (Landing, NJ) |
|Assignee:|| Warner-Lambert Company (Morris Plains, NJ) |
Patent Claim Types:|
see list of patent claims
|Composition; Dosage form; Process; |
Foreign Priority and PCT Information for Patent: 6,500,456
|PCT Filed||September 16, 1998||PCT Application Number:||PCT/US98/19356|
|PCT Publication Date:||April 15, 1999||PCT Publication Number:||
International Patent Family for Patent: 6,500,456
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