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Serving hundreds of leading biopharmaceutical companies globally:

Express Scripts
Accenture
Farmers Insurance
Queensland Health
McKesson
Medtronic
Dow
US Department of Justice
Chinese Patent Office

Generated: April 19, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,444,652

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Which drugs does patent 6,444,652 protect, and when does it expire?

Patent 6,444,652 protects TYZEKA and is included in two NDAs.

This patent has forty-four patent family members in twenty countries.
Summary for Patent: 6,444,652
Title: .beta.-L-2'-deoxy-nucleosides for the treatment of hepatitis B
Abstract:This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2'-deoxy-.beta.-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof, wherein the 2'-deoxy-.beta.-L-erythro-pentofuranonucleoside has the formula: ##STR1## wherein R is selected from the group consisting of H, straight chained, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, mono, di, or triphosphate, or a phosphate derivative; and BASE is a purine or pyrimidine base which may be optionally substituted. The 2'-deoxy-.beta.-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof may be administered either alone or in combination with another 2'-deoxy-.beta.-L-erythro-pentofuranonucleoside or in combination with another anti-hepatitis B agent.
Inventor(s): Gosselin; Gilles (Montpellier, FR), Imbach; Jean-Louis (Montpellier, FR), Bryant; Martin L. (Carlisle, MA)
Assignee: Novirio Pharmaceuticals Limited (Grand Cayman, CY) Centre National da la Recherche Scientifique (Paris, FR)
Application Number:09/459,150
Patent Claim Types:
see list of patent claims
Use; Compound; Composition;

Drugs Protected by US Patent 6,444,652

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Novartis TYZEKA telbivudine SOLUTION;ORAL 022154-001 Apr 28, 2009 DISCN No No ➤ Try a Free Trial ➤ Try a Free Trial TREATMENT OF CHRONIC HEPATITIS B IN ADULT PATIENTS ➤ Try a Free Trial
Novartis TYZEKA telbivudine TABLET;ORAL 022011-001 Oct 25, 2006 DISCN Yes No ➤ Try a Free Trial ➤ Try a Free Trial TREATMENT OF CHRONIC HEPATITIS B IN ADULT PATIENTS WITH EVIDENCE OF VIRAL REPLICATION AND EITHER EVIDENCE OF PERSISTANT ELEVATIONS IN SERUM AMINOTRANSFERASES (ALT OR AST) OR HISTOLOGICALLY ACTIVE DISEASE ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 6,444,652

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
6,566,344 .beta.-L-2'-deoxy-nucleosides for the treatment of hepatitis B ➤ Try a Free Trial
6,569,837 .beta.-L-2'-deoxy pyrimidine nucleosides for the treatment of hepatitis B ➤ Try a Free Trial
6,946,450 .beta.-L-2'-deoxy-nucleosides for the treatment of hepatitis B ➤ Try a Free Trial
2,011,195,922 ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 6,444,652

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Singapore 132498 ➤ Try a Free Trial
Russian Federation 2424016 ➤ Try a Free Trial
Russian Federation 2006147216 ➤ Try a Free Trial
Russian Federation 2300381 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Cerilliant
McKesson
Merck
Mallinckrodt
Deloitte
Medtronic
Accenture
Cipla
UBS

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