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|Title:||Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes|
|Abstract:||This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a VEGF Nucleic Acid Ligand by SELEX methodology and associating the VEGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more VEGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a VEGF Nucleic Acid Ligand or Complex and methods for making the same.|
|Inventor(s):||Janjic; Nebojsa (Boulder, CO), Gold; Larry (Boulder, CO), Schmidt; Paul (Niwot, CO), Vargeese; Chandra (Thornton, CO), Willis; Michael (Louisville, CO)|
|Assignee:||Gilead Sciences, Inc. (Foster City, CA)|
Patent Claim Types:|
see list of patent claims
|PCT Filed||October 17, 1997||PCT Application Number:||PCT/US97/18944|
|PCT Publication Date:||May 07, 1998||PCT Publication Number:||WO98/18480|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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