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|Title:||Process for the preparation of a solid pharmaceutical dosage form|
|Abstract:||A process for the preparation of a solid pharmaceutical dosage form comprising a carrier and, as active ingredient, a compound which exists, in solution, in an equilibrium between a free acid or free base form and a salt form, and for which there is a difference in volatility between the free acid or free base form and the salt form. The process includes the steps of solidifying a mixture of the compound and carrier in a solvent, and subsequently removing the solvent from the solidified mixture. A pH modifier is added to the mixture prior to solidification to shift the equilibrium to favor the less volatile form of the active ingredient.|
|Inventor(s):||Jordan; Andrew William (Swindon, GB), Saunders; Joy Elaine (Faringdon, GB), Kearney; Patrick (Swindon, GB)|
|Assignee:||R. P. Scherer Corporation (St. Petersburg, FL)|
Patent Claim Types:|
see list of patent claims
|Composition; Compound; Dosage form; Process;|
Back Citations: 10th percentile
Forward Citations: 0th percentile
|Foriegn Application Priority Data|
|Foreign Country||Foreign Patent Number||Foreign Patent Date|
|United Kingdom||9504201||Mar 02, 1995|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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