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Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
Johnson and Johnson
Daiichi Sankyo
Fish and Richardson
Argus Health
Healthtrust
Cerilliant
AstraZeneca
Moodys

Generated: July 16, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,419,953

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Which drugs does patent 6,419,953 protect, and when does it expire?

Patent 6,419,953 protects DEPAKOTE ER and is included in one NDA.

Protection for DEPAKOTE ER has been extended six months for pediatric studies, as indicated by the *PED designation in the table below.

This patent has thirty-seven patent family members in twenty-seven countries.
Summary for Patent: 6,419,953
Title: Controlled release formulation of divalproex sodium
Abstract:The present invention pertains to a hydrophilic matrix tablet suitable for the once-a-day administration of valproate compounds such as divalproex sodium. The tablet comprises from about 50 weight percent to about 55 weight percent of an active ingredient selected from the group consisting of valproic acid, a pharmaceutically acceptable salt or ester of valproic acid, divalproex sodium, and valpromide; from about 20 weight percent to about 40 weight percent hydroxypropyl methylcellulose; from about 5 weight percent to about 15 weight percent lactose, from about 4 weight percent to about 6 weight percent microcrystalline cellulose, and from about 1 weight percent to about 5 weight percent of silicon dioxide; all weight percentages based upon the total weight of the tablet dosage form. Other aspects of the invention relate to the use of this formulation in the treatment of epilepsy and to methods for manufacturing this dosage form.
Inventor(s): Qiu; Yihong (Gurnee, IL), Poska; Paul Richard (Mundelein, IL), Cheskin; Howard S. (Glencoe, IL), Bollinger; J. Daniel (Libertyville, IL), Engh; Robert K. (Kenosha, WI)
Assignee: Abbott Laboratories (Abbott Park, IL)
Application Number:09/216,650
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,419,953
Patent Claim Types:
see list of patent claims
Compound; Dosage form; Formulation; Composition; Use;

Drugs Protected by US Patent 6,419,953

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Abbvie DEPAKOTE ER divalproex sodium TABLET, EXTENDED RELEASE;ORAL 021168-001 Aug 4, 2000 AB RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate

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Non-Orange Book US Patents Family Members for Patent 6,419,953

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
6,720,004 Controlled release formulation of divalproex sodium ➤ Try a Free Trial
6,511,678 Controlled release formulation of divalproex sodium ➤ Try a Free Trial
6,528,091 Controlled release formulation of divalproex sodium ➤ Try a Free Trial
6,713,086 Controlled release formulation of divalproex sodium ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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International Family Members for US Patent 6,419,953

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Taiwan 585788 ➤ Try a Free Trial
Turkey 200402549 ➤ Try a Free Trial
Slovakia 8252001 ➤ Try a Free Trial
Slovenia 20624 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

UBS
US Department of Justice
Chubb
McKesson
Fuji
Julphar
Accenture
Covington
Johnson and Johnson

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