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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Cipla
Colorcon
US Army
McKinsey
Farmers Insurance
Queensland Health
QuintilesIMS
AstraZeneca
Harvard Business School

Generated: February 22, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,406,713

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Which drugs does patent 6,406,713 protect, and when does it expire?

Patent 6,406,713 protects ABELCET and is included in one NDA.

This patent has forty-six patent family members in twenty-four countries.
Summary for Patent: 6,406,713
Title: Methods of preparing low-toxicity drug-lipid complexes
Abstract:Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
Inventor(s): Janoff; Andrew S. (Yardley, PA), Madden; Thomas D. (Vancouver, CA), Cullis; Pieter R. (Vancouver, CA), Kearns; John J. (Princeton, NJ), Durning; Anthony G. (Yardley, PA)
Assignee: The Liposome Company, Inc. (Princeton, NJ)
Application Number:08/430,661
Patent Claim Types:
see list of patent claims
Use; Formulation; Dosage form;

Drugs Protected by US Patent 6,406,713

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Leadiant Biosci Inc ABELCET amphotericin b INJECTABLE, LIPID COMPLEX;INJECTION 050724-001 Nov 20, 1995 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 6,406,713

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
4,963,297 Spontaneous vesticulation of multilamellar liposomes ➤ Try a Free Trial
5,616,334 Low toxicity drug-lipid systems ➤ Try a Free Trial
5,948,441 Method for size separation of particles ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 6,406,713

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 113468 ➤ Try a Free Trial
Austria 118169 ➤ Try a Free Trial
Australia 1799088 ➤ Try a Free Trial
Australia 622405 ➤ Try a Free Trial
Canada 1330199 ➤ Try a Free Trial
Canada 1337273 ➤ Try a Free Trial
Canada 1338701 ➤ Try a Free Trial
China 1044093 ➤ Try a Free Trial
China 88101864 ➤ Try a Free Trial
Germany 3852037 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Express Scripts
Mallinckrodt
UBS
Federal Trade Commission
Daiichi Sankyo
Colorcon
Merck
Dow
McKinsey

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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