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Last Updated: November 12, 2019

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Details for Patent: 6,406,713

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Which drugs does patent 6,406,713 protect, and when does it expire?

Patent 6,406,713 protects ABELCET and is included in one NDA.

This patent has forty-six patent family members in twenty-four countries.

Summary for Patent: 6,406,713
Title: Methods of preparing low-toxicity drug-lipid complexes
Abstract:Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
Inventor(s): Janoff; Andrew S. (Yardley, PA), Madden; Thomas D. (Vancouver, CA), Cullis; Pieter R. (Vancouver, CA), Kearns; John J. (Princeton, NJ), Durning; Anthony G. (Yardley, PA)
Assignee: The Liposome Company, Inc. (Princeton, NJ)
Application Number:08/430,661
Patent Claim Types:
see list of patent claims
Use; Formulation; Dosage form;

Drugs Protected by US Patent 6,406,713

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Leadiant Biosci Inc ABELCET amphotericin b INJECTABLE, LIPID COMPLEX;INJECTION 050724-001 Nov 20, 1995 RX Yes Yes   Start Trial   Start Trial Y   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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Serving leading biopharmaceutical companies globally:

Harvard Business School
Johnson and Johnson
Merck
Express Scripts
Colorcon
Boehringer Ingelheim

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