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Fish and Richardson

Generated: May 26, 2018

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Details for Patent: 6,391,874

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Summary for Patent: 6,391,874
Title: Fused heterocyclic compounds as protein tyrosine kinase inhibitors
Abstract:Substituted heteroaromatic compounds of formula (I) and in particular substituted quinolines and quinazolines, are protein tyrosine kinase inhibitors. The compounds are described as are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine, for example in the treatment of cancer and psoriasis, or a salt or solvate thereof; wherein X is N or CH; Y is a group W(CH.sub.2), (CH.sub.2)W, or W, in which W is O, S(O).sub.m wherein m is 0, 1 or 2, or NR.sup.a wherein R.sup.a is hydrogen or a C.sub.1-8 alkyl group; R.sup.1 represents a phenyl group or a 5- or 6-membered heterocyclic ring containing 1 to 4 heteroatoms selected from N, O or S(O).sub.m, wherein m is as defined above, with the provisos that the ring does not contain two adjacent O or S(O).sub.m atoms and that where the ring contains only N as heteroatom(s) the ring is C-linked to the quinazoline or quinoline ring, R.sup.1 being optionally substituted by one or more R.sup.3 ;groups; P=0 to 3; U, R.sup.2, R.sup.3 are as defined in the application. ##STR1##
Inventor(s): Cockerill; George Stuart (Herts, GB), Carter; Malcolm Clive (Herts, GB), Guntrip; Stephen Barry (Herts, GB), Smith; Kathryn Jane (Herts, GB)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Application Number:09/214,267
Patent Claim Types:
see list of patent claims
Compound; Composition; Formulation; Dosage form; Use;

Drugs Protected by US Patent 6,391,874

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 6,391,874

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9614755Jul 13, 1996
United Kingdom9625458Dec 07, 1996
PCT Information
PCT FiledJuly 11, 1997PCT Application Number:PCT/EP97/03672
PCT Publication Date:January 22, 1998PCT Publication Number: WO98/02434

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