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Last Updated: October 21, 2020

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Details for Patent: 6,225,474

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Summary for Patent: 6,225,474
Title: Polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and method of producing the same
Abstract:The present invention provides a technique of selectively producing a desired polymorph of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid. The present invention also provides a method of producing various polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, which comprises crystallizing under the conditions defined by a specific temperature and a composition of a mixed solvent of methanol and water, and polymorphs obtained by the method. The present invention further provides a method of producing the other polymorphs or amorphous compounds by drying a specific polymorph under a reduced pressure with heating, and the other polymorphs or amorphous compounds obtained by the method.
Inventor(s): Matsumoto; Koichi (Iwakuni, JP), Watanabe; Kenzo (Iwakuni, JP), Hiramatsu; Toshiyuki (Iwakuni, JP), Kitamura; Mitsutaka (Higashi-Hiroshima, JP)
Assignee: Teijin Limited (Osaka, JP)
Application Number:09/485,861
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,225,474
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 6,225,474

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 6,225,474

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan10-173079Jun 19, 1998
PCT Information
PCT FiledJune 18, 1999PCT Application Number:PCT/JP99/03258
PCT Publication Date:December 23, 1999PCT Publication Number: WO99/65885

International Family Members for US Patent 6,225,474

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 449765   Start Trial
Austria 522512   Start Trial
Australia 4289299   Start Trial
Australia 748026   Start Trial
Bulgaria 104159   Start Trial
Bulgaria 64734   Start Trial
Brazil 9906539   Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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