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Serving leading biopharmaceutical companies globally:

Fish and Richardson
US Department of Justice
Johnson and Johnson
Cantor Fitzgerald

Generated: November 23, 2017

DrugPatentWatch Database Preview

Details for Patent: 6,222,025

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Summary for Patent: 6,222,025

Title: Process for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom
Abstract:Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2' and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position. Improved processes for the synthesis of 2'-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2'-anhydropyrimidine nucleoside or a 2S,2'-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.
Inventor(s): Cook; Phillip Dan (Escondido, CA), Sanghvi; Yogesh S. (Encinitas, CA), Sprankle; Kelly G. (Vista, CA), Ross; Bruce S. (Carlsbad, CA), Griffey; Rich H. (Vista, CA), Springer; Robert H. (Carlsbad, CA)
Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA)
Application Number:08/894,899
Patent Claim Types:
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Foreign Priority and PCT Information for Patent: 6,222,025

PCT Information
PCT FiledMarch 06, 1996PCT Application Number:PCT/US96/03174
PCT Publication Date:September 12, 1996PCT Publication Number: WO96/27606

International Patent Family for Patent: 6,222,025

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Canada2214535► Subscribe
Germany69636160► Subscribe
European Patent Office0813539► Subscribe
Japan2001097994► Subscribe
Japan3787265► Subscribe
Australia5359496► Subscribe
Norway974077► Subscribe
JapanH10512894► Subscribe
Austria327244► Subscribe
World Intellectual Property Organization (WIPO)9627606► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
Express Scripts
Farmers Insurance
Fish and Richardson
US Department of Justice

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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