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Serving leading biopharmaceutical companies globally:

US Army
Harvard Business School
Farmers Insurance
US Department of Justice

Generated: November 22, 2017

DrugPatentWatch Database Preview

Details for Patent: 6,162,463

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Summary for Patent: 6,162,463

Title: Extended release formulation of diltiazem hydrochloride
Abstract:An extended release formulation of diltiazem which is suitable for once-daily oral administration comprises a quantity of a quick release preparation of diltiazem or a pharmaceutically active salt thereof, mixed with a quantity of a slow release (or delayed release) preparation of diltiazem or a pharmaceutically active salt thereof. The quick release preparation used obtains a maximal release of diltiazem within approximately 1-2 hours after administration, and then falls toward baseline levels. The delayed release preparation individually shows a maximal release of diltiazem at between approximately 6-8 hours after administration. The formulation containing the two preparation achieves a maximal release of diltiazem approximately within 1-2 hours after administration, and the levels of released diltiazem remain near these maximal levels for approximately another 12 hours after administration, compared to other extended release formulations of diltiazem (referred to herein as slow or delayed release preparations) which achieve maximal release approximately 9 hours after oral administration. The preferred embodiment is a capsule containing the formulation, which, based upon the total quantity of drug in the formulation rather than total weight of the formulation, comprises up to approximately 25 percent by weight of the quick release preparation of diltiazem, and up to 75 percent by weight of the slow (or delayed) release preparation of diltiazem. The present invention has application for combinations of other preparations of quick release and slow or delayed release pharmaceuticals.
Inventor(s): Lippa; Arnold S. (Hackensack, NJ)
Application Number:09/067,573
Patent Claim Types:
see list of patent claims
Formulation; Compound; Dosage form; Use;

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International Patent Family for Patent: 6,162,463

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office0953350► Subscribe
Japan2000026278► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
US Department of Justice
Fish and Richardson
Federal Trade Commission

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ISSN: 2162-2639

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