|Title:||Multivesicular liposomes with controlled release of active agents encapsulated in the presence of a hydrochloride|
|Abstract:||Disclosed are multivesicular liposomes containing biologically active substances, and having defined size distribution, adjustable average size, adjustable internal chamber size and number, and a modulated release of the biologically active substance. The liposomes are made by a process comprising dissolving a lipid component in volatile organic solvents, adding an immiscible aqueous component containing at least one biologically active substance to be encapsulated, and adding to either or both the organic solvents and the lipid component, a hydrochloride effective to control the release rate of the biologically active substance from the multivesicular liposome. A water-in-oil emulsion is made from the two components, the emulsion is immersed into a second aqueous component, and then divided into small solvent spherules which contain even smaller aqueous chambers. The solvents arc finally removed to give an aqueous suspension of multivesicular liposomes encapsulating biologically active substances.|
|Inventor(s):||Kim; Sinil (Solana Beach, CA), Howell; Stephen B. (Del Mar, CA)|
|Assignee:||SkyePharma Inc. (San Diego, CA)|
Patent Claim Types:|
see list of patent claims
|Dosage form; Process; Device;|
Field: Not categorized
Back Citations: 32nd percentile
Forward Citations: 1st percentile
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