Generated: December 18, 2017
DrugPatentWatch Database Preview
Details for Patent: 6,039,974
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Which drugs does patent 6,039,974 protect, and when does it expire?
Summary for Patent: 6,039,974
|Title:|| Pharmaceutical composition for combination of piperidinoalkanol-decongestant|
|Abstract:||The present invention provides a pharmaceutical composition in the form of a bilayer tablet comprising, (a) a first discrete zone made with Formulation (A) which comprises, a therapeutically effective decongestant amount of a sympathomimetic drug, or a pharmaceutically acceptable salt thereof, in an amount of about 18% to about 39% by weight of Formulation (A), and a first carrier base material, the first carrier base material comprising a mixture of; (I) carnauba wax in an amount of about 59% to about 81% by weight of Formulation (A); and (ii) a suitable antiadherent in an amount of about 0.25% to about 2.00% by weight of Formulation (A); wherein said first carrier base material provides a sustained release of the sympathomimetic drug; and (b) a second discrete zone made with Formulation (B) which comprises a therapeutically effective antihistaminic amount of a piperidinoalkanol, or a pharmaceutically acceptable salt thereof, in an amount of about 15% to about 30% by weight of Formulation (B) and a second carrier base material, the second carrier base comprising a mixture of; (I) a cellulose diluent in an amount of about 27% to about 73% by weight of Formulation (B); (ii) pregelatinized starch in an amount of about 15% to about 30% by weight of Formulation (B); (iii) a suitable disintegrant in an amount of about 0.25% to about 6.00% by weight of Formulation (B); and (iv) a suitable lubricant in an amount of about 0.25% to about 2.00% by weight of Formulation (B); wherein said second carrier base material provides an immediate release of the piperidinoalkanol or the pharmaceutically acceptable salt thereof.|
|Inventor(s):|| MacLaren; David D. (Overland Park, KS), Lefler; John R. (Overland Park, KS), Minish; Sharon K. (Independence, MO) |
|Assignee:|| Hoechst Marion Roussel, Inc. (Bridgewater, NJ) |
Patent Claim Types:|
see list of patent claims
|Composition; Dosage form; Compound; |
International Patent Family for Patent: 6,039,974
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