Details for Patent: 6,017,922

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Summary for Patent: 6,017,922

Title:	Thermally stable trimetrexates and processes for producing the same
Abstract:	The present invention provides for thermally stable forms of 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline, or trimetrexate. A crystalline 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline monohydrate, or trimetrexate monohydrate, belonging to the space group P1(#2) and having a triclinic cell with dimensions of about a=7.699 .ANG., b=9.606 .ANG. and c=13.012 .ANG. is disclosed. A novel Schiff base compound, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyphenylimino)-methinyl]quinazoline , is also disclosed. The present invention further provides novel methods of producing stable trimetrexate free base compounds, including crystalline trimetrexate monohydrate. The crystalline monohydrate form provides increased stability over the anhydrous form.
Inventor(s):	Stogniew; Martin (Blue Bell, PA), Grafe; Ingomar (Nurnberg, DE), Morsdorf; Johann (Langenzenn, DE)
Assignee:	U.S. Bioscience, Inc. (Conshohocken, PA)
Application Number:	09/080,290
Patent Claim Types: see list of patent claims	Compound; Composition;

Drugs Protected by US Patent 6,017,922

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International Family Members for US Patent 6,017,922

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Australia	4081799	See Plans and Pricing
Brazil	9910543	See Plans and Pricing
Canada	2333274	See Plans and Pricing
European Patent Office	1080079	See Plans and Pricing
Japan	2002515493	See Plans and Pricing
>Country	>Patent Number	>Estimated Expiration	>Supplementary Protection Certificate	>SPC Country	>SPC Expiration

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