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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
McKesson
McKinsey
US Department of Justice
Cantor Fitzgerald
Queensland Health
Covington
US Army
Medtronic

Generated: April 21, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,965,156

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Summary for Patent: 5,965,156
Title: Amphotericin B liposome preparation
Abstract:A novel composition and method for solubilizing amphiphilic drugs in a small amount of organic solvent for use in improved liposomes is disclosed. A phosphatidylglycerol is acidified in a small amount of organic solvent. The amphiphilic drug, such as Amphotericin B, suspended in organic solvent is then added to the acidified phosphatidylycerol and a soluble complex is formed between the phosphatidylglycerol and the amphiphilic drug. When the liposome composition incorporating the soluble complex is hydrated, the final pH of the hydrating aqueous buffer is carefully controlled. The Amphotericin B liposomes formed have markedly reduced toxicity.
Inventor(s): Proffitt; Richard T. (Arcadia, CA), Adler-Moore; Jill (Altadena, CA), Chiang; Su-Ming (Canoga Park, CA)
Assignee: NeXstar Pharmaceuticals, Inc. (Boulder, CO)
Application Number:08/469,251
Patent Claim Types:
see list of patent claims
Compound; Process; Dosage form; Use;

Drugs Protected by US Patent 5,965,156

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,965,156

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Germany 3864495 ➤ Try a Free Trial
Denmark 629388 ➤ Try a Free Trial
Greece 3003050 ➤ Try a Free Trial
Spain 2029330 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

AstraZeneca
US Army
Harvard Business School
Daiichi Sankyo
Express Scripts
Healthtrust
Teva
Boehringer Ingelheim
Julphar

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