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Serving leading biopharmaceutical companies globally:

Merck
McKesson
Deloitte
Express Scripts
Farmers Insurance
UBS
QuintilesIMS
Chubb
Fish and Richardson
Queensland Health

Generated: February 25, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,965,156

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Summary for Patent: 5,965,156
Title: Amphotericin B liposome preparation
Abstract:A novel composition and method for solubilizing amphiphilic drugs in a small amount of organic solvent for use in improved liposomes is disclosed. A phosphatidylglycerol is acidified in a small amount of organic solvent. The amphiphilic drug, such as Amphotericin B, suspended in organic solvent is then added to the acidified phosphatidylycerol and a soluble complex is formed between the phosphatidylglycerol and the amphiphilic drug. When the liposome composition incorporating the soluble complex is hydrated, the final pH of the hydrating aqueous buffer is carefully controlled. The Amphotericin B liposomes formed have markedly reduced toxicity.
Inventor(s): Proffitt; Richard T. (Arcadia, CA), Adler-Moore; Jill (Altadena, CA), Chiang; Su-Ming (Canoga Park, CA)
Assignee: NeXstar Pharmaceuticals, Inc. (Boulder, CO)
Application Number:08/469,251
Patent Claim Types:
see list of patent claims
Compound; Process; Dosage form; Use;

Drugs Protected by US Patent 5,965,156

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,965,156

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 66598 ➤ Sign Up
Australia 2416188 ➤ Sign Up
Australia 598958 ➤ Sign Up
Canada 1339008 ➤ Sign Up
Germany 3864495 ➤ Sign Up
Denmark 175052 ➤ Sign Up
Denmark 629388 ➤ Sign Up
European Patent Office 0317120 ➤ Sign Up
Spain 2029330 ➤ Sign Up
Greece 3003050 ➤ Sign Up
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
Merck
McKesson
Moodys
Healthtrust
UBS
Chubb
Chinese Patent Office
Express Scripts

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