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Last Updated: November 28, 2023

Details for Patent: 5,925,730

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Summary for Patent: 5,925,730

Title:	GnRH antagonists
Abstract:	Peptides are provided which have improved duration of GnRH antagonistic properties. These antagonists may be used to regulate fertility and to treat steroid-dependent tumors and for other short-term and long-term treatment indications. These antagonists have a derivative of aminoPhe or its equivalent in the 5- and/or 6-positions. This derivative contains a carbamoyl group or a heterocycle including a urea in its side chain. Particularly effective decapeptides, which continue to exhibit very substantial suppression of LH secretion at 96 hours following injection, have the formulae: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-4Aph(hydroorotyl)-D-4Aph(acetyl)-Leu-Lys(isopr opyl)-Pro-D-Ala-NH.sub.2, and Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-4Aph(hydroorotyl)-D-4Amf(Q.sub.2)-Leu-Lys(isop ropyl)-Pro-D-Ala-NH.sub.2, wherein Q.sub.2 is Cbm or MeCbm.
Inventor(s):	Semple; Graeme (Hampshire, GB), Jiang; Guangcheng (San Diego, CA)
Assignee:	Ferring BV (Hoofddorp, NL)
Application Number:	08/837,042
Patent Claim Types: see list of patent claims	Compound; Use; Composition;

Drugs Protected by US Patent 5,925,730

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>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Argentina	011217	⤷ Try a Trial
Austria	319736	⤷ Try a Trial
Australia	6969898	⤷ Try a Trial
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Brazil	9808523	⤷ Try a Trial
Canada	2286190	⤷ Try a Trial
China	1230442	⤷ Try a Trial
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