In a needle-less injector combining an actuator and a medicament cartridge, the actuator includes a housing with a forward portion to which the cartridge is connected. An impact member is mounted within the housing inward of the forward portion so as to be movable toward the forward portion, where it may strike components of the cartridge to effect expulsion of a dose of medicament. A chamber is provided within the housing and is pre-filled with a pressurized gas which is in communication with and exerts a constant force on the impact member, tending to urge it towards the forward portion. Movement of the impact member is prevented by a latch which normally engages the impact member and prevents its forward movement, but is actuable to be moved out of such engagement, permitting movement of the impact member, the cartridge includes a piston which is mounted in the body of the cartridge with an interference fit and is made of a material which is substantially non-resilient when subjected to a slowly applied force, but is highly resilient when subjected to a rapidly applied force.
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