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Serving leading biopharmaceutical companies globally:

Cipla
Boehringer Ingelheim
Farmers Insurance
Medtronic
Dow
Teva
AstraZeneca
Fish and Richardson
Express Scripts
Cerilliant

Generated: January 17, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,886,184

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Summary for Patent: 5,886,184
Title: Finasteride processes
Abstract:Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17.beta.-carboalkoxy-4-aza-5.alpha.-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride. Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.
Inventor(s): Dolling; Ulf H. (Westfield, NJ), McCauley; James A. (Belle Mead, NJ), Varsolona; Richard J. (Scotch Plains, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:08/824,426
Patent Claim Types:
see list of patent claims
Compound; Process;

Drugs Protected by US Patent 5,886,184

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,886,184

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Croatia P931410 ➤ Subscribe
Iceland 4094 ➤ Subscribe
Israel 125769 ➤ Subscribe
China 1090583 ➤ Subscribe
China 1058018 ➤ Subscribe
Cyprus 2135 ➤ Subscribe
Czech Republic 9501268 ➤ Subscribe
Czech Republic 287842 ➤ Subscribe
Czech Republic 301160 ➤ Subscribe
Czech Republic 301191 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Teva
Healthtrust
Federal Trade Commission
Mallinckrodt
Queensland Health
Covington
Merck
Chinese Patent Office
Dow

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