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Serving hundreds of leading biopharmaceutical companies globally:

Express Scripts
Julphar
Mallinckrodt
US Army
Cerilliant
Covington
Moodys
Chubb
Chinese Patent Office

Generated: May 25, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,886,184

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Summary for Patent: 5,886,184
Title: Finasteride processes
Abstract:Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17.beta.-carboalkoxy-4-aza-5.alpha.-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride. Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.
Inventor(s): Dolling; Ulf H. (Westfield, NJ), McCauley; James A. (Belle Mead, NJ), Varsolona; Richard J. (Scotch Plains, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:08/824,426
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 5,886,184
Patent Claim Types:
see list of patent claims
Compound; Process;

Drugs Protected by US Patent 5,886,184

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Family Members for US Patent 5,886,184

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 164850 ➤ Try a Free Trial
Austria 177112 ➤ Try a Free Trial
Australia 5078793 ➤ Try a Free Trial
Australia 658774 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
AstraZeneca
QuintilesIMS
Cantor Fitzgerald
Medtronic
Express Scripts
Fish and Richardson
UBS
McKinsey

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