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Serving leading biopharmaceutical companies globally:

Merck
US Army
Argus Health
Baxter
Colorcon
Mallinckrodt
Johnson and Johnson
AstraZeneca
Moodys
Harvard Business School

Generated: February 25, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,723,147

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Summary for Patent: 5,723,147
Title: Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
Abstract:Disclosed are multivesicular liposomes containing biologically active substances, the multivesicular liposomes having defined size distribution, adjustable average size, adjustable internal chamber size and number, and a modulated rate of the biologically active substance in contrast to the previous art. The process comprises dissolving a lipid component in volatile organic solvents, adding an immiscible aqueous component containing at least one biologically active substance to be encapsulated, and adding to either or both the organic solvents and the lipid component, a hydrochloride effective to control the release rate of the biologically active substance from the multivesicular liposome, making a water-in-oil emulsion from the two components, immersing the emulsion into a second aqueous component, dividing the emulsion into small solvent spherules which contain even smaller aqueous chambers, and then removing the solvents to give an aqueous suspension of multivesicular liposomes encapsulating biologically active substances.
Inventor(s): Kim; Sinil (Solana Beach, CA), Howell; Stephen B. (Del Mar, CA)
Assignee: DepoTech Corporation (La Jolla, CA)
Application Number:08/472,126
Patent Claim Types:
see list of patent claims
Dosage form; Composition; Use; Compound;

Drugs Protected by US Patent 5,723,147

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 5,723,147

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8704171Feb 23, 1987

International Patents Family Members for US Patent 5,723,147

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 87823 ➤ Sign Up
Australia 1205588 ➤ Sign Up
Australia 602190 ➤ Sign Up
Canada 1323568 ➤ Sign Up
Germany 3879987 ➤ Sign Up
Denmark 172057 ➤ Sign Up
Denmark 93988 ➤ Sign Up
European Patent Office 0280503 ➤ Sign Up
Spain 2053722 ➤ Sign Up
Finland 880841 ➤ Sign Up
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Colorcon
Farmers Insurance
Fuji
Cipla
Healthtrust
Chubb
Medtronic
US Department of Justice
QuintilesIMS

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