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Generated: February 20, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,705,517

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Summary for Patent: 5,705,517
Title: Benzimidazole derivatives and use thereof
Abstract:Benzimidazole derivatives of the formula (I): ##STR1## wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R' is hydrogen or an optionally substituted hydrocarbon residue; R.sup.2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R' is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is --O--, --S(O).sub.m -- or --N(R.sup.4)-- wherein m is an integer of 0, 1 or 2 and R.sup.4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.
Inventor(s): Naka; Takehiko (Kobe, JP), Nishikawa; Kohei (Kyoto, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:08/131,667
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 5,705,517

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 5,705,517

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan2-113148Apr 19, 1990
Japan2-141942May 30, 1990
Japan2-208662Aug 06, 1990
Japan2-264579Oct 01, 1990
Japan2-413679Dec 24, 1990

International Patents Family Members for US Patent 5,705,517

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Finland 108434 ➤ Try a Free Trial
Finland 911936 ➤ Try a Free Trial
Japan H04364171 ➤ Try a Free Trial
Israel 97882 ➤ Try a Free Trial
Ireland 911317 ➤ Try a Free Trial
Hungary 210871 ➤ Try a Free Trial
Hungary 213266 ➤ Try a Free Trial
Hungary T57736 ➤ Try a Free Trial
Hungary 911347 ➤ Try a Free Trial
Hong Kong 1000803 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Medtronic
Argus Health
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Express Scripts
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Harvard Business School
Johnson and Johnson
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UBS

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