Generated: December 17, 2017
DrugPatentWatch Database Preview
Details for Patent: 5,703,110
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Summary for Patent: 5,703,110
|Title:|| Benzimidazole derivatives, their production and use|
|Abstract:||Benzimidazole derivatives of the formula (I): ##STR1## wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R.sup.1 is hydrogen or an optionally substituted hydrocarbon residue; R.sup.2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R' is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is --O--, --S(O).sub.m -- or --N(R.sup.4)-- wherein m is an integer of 0, 1 or 2 and R.sup.4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.|
|Inventor(s):|| Naka; Takehiko (Kobe, JP), Nishikawa; Kohei (Kyoto, JP), Kato; Takeshi (Higashiosaka, JP) |
|Assignee:|| Takeda Chemical Industries, Ltd. (Osaka, JP) |
Patent Claim Types:|
see list of patent claims
|Compound; Composition; Use; |
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Foreign Priority and PCT Information for Patent: 5,703,110
|Foriegn Application Priority Data|
||Foreign Patent Number
||Foreign Patent Date
|Japan||2-113148||Apr 27, 1990|
|Japan||2-141942||May 30, 1990|
|Japan||2-208662||Aug 06, 1990|
|Japan||2-264579||Oct 01, 1990|
|Japan||2-413679||Dec 24, 1990|
International Patent Family for Patent: 5,703,110
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