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Last Updated: January 17, 2020

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Details for Patent: 5,681,588

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Summary for Patent: 5,681,588
Title: Delayed release microtablet of .beta.-phenylpropiophenone derivatives
Abstract:A cylindrical delayed release tablet with a convex or flat upper side and lower side is provided, along with a method for its production and a gelatin capsule containing 3-200 tablets of the same having identical or different release rates, wherein the tablet if made of .beta.-phenylpropiophenone derivatives of the formula I as active ingredient ##STR1## where R is n-propyl or 1,1-dimethylpropyl, and their pharmacologically acceptable salts, wherein the tablet has a height and diameter that are both, independently of one another, 1-3 mm, the active ingredient content is in the range from 81-99.9% of the weight of the microtablet, (but not taking into account the weight of any coating which is present, the active ingredient density is greater than 1, the release of active ingredient in the USP paddle method at 50 rpm is 80% as a maximum after 3 hours and as a minimum after 24 hours, the release rate is virtually independent of the pressure when compressing the tablets, and the tablet contains no release-delaying ancillary substance but can contain 0.1-5% by weight of a lubricant and 0-18.9% by weight of other conventional ancillary substances.
Inventor(s): Kolter; Karl (Limburgerhof, DE), Fricke; Helmut (Mutterstadt, DE), Buehler; Volker (Karlsruhe, DE), Mueller-Peltzer; Herbert (Heidelberg, DE)
Assignee: Knoll Aktiengesellschaft (Ludwigshafen, DE)
Application Number:08/525,749
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 5,681,588
Patent Claim Types:
see list of patent claims
Compound; Dosage form; Composition; Process;

Drugs Protected by US Patent 5,681,588

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 5,681,588

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany43 10 963.2Apr 03, 1993
PCT Information
PCT FiledMarch 24, 1994PCT Application Number:PCT/EP94/00949
PCT Publication Date:October 03, 1994PCT Publication Number: WO94/22434

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