|Title:||Delayed release microtablet of .beta.-phenylpropiophenone derivatives|
|Abstract:||A cylindrical delayed release tablet with a convex or flat upper side and lower side is provided, along with a method for its production and a gelatin capsule containing 3-200 tablets of the same having identical or different release rates, wherein the tablet if made of .beta.-phenylpropiophenone derivatives of the formula I as active ingredient ##STR1## where R is n-propyl or 1,1-dimethylpropyl, and their pharmacologically acceptable salts, wherein the tablet has a height and diameter that are both, independently of one another, 1-3 mm, the active ingredient content is in the range from 81-99.9% of the weight of the microtablet, (but not taking into account the weight of any coating which is present, the active ingredient density is greater than 1, the release of active ingredient in the USP paddle method at 50 rpm is 80% as a maximum after 3 hours and as a minimum after 24 hours, the release rate is virtually independent of the pressure when compressing the tablets, and the tablet contains no release-delaying ancillary substance but can contain 0.1-5% by weight of a lubricant and 0-18.9% by weight of other conventional ancillary substances.|
|Inventor(s):||Kolter; Karl (Limburgerhof, DE), Fricke; Helmut (Mutterstadt, DE), Buehler; Volker (Karlsruhe, DE), Mueller-Peltzer; Herbert (Heidelberg, DE)|
|Assignee:||Knoll Aktiengesellschaft (Ludwigshafen, DE)|
Patent Claim Types:|
see list of patent claims
|Compound; Dosage form; Composition; Process;|
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