Generated: December 12, 2017
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Details for Patent: 5,616,582
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Summary for Patent: 5,616,582
|Title:|| Quinazoline derivatives as anti-proliferative agents|
|Abstract:||The invention concerns quinazoline derivatives of the formula I ##STR1## wherein m is 1, 2 or 3 and each R.sup.1 includes hydroxy, amino, carboxy, carbamoyl, ureido, (1-4C)alkoxycarbonyl, N-(1-4C)alkylcarbamoyl, N,N-di-[(1-4C)alkyl]carbamoyl, hydroxyamino, (1-4C)alkoxyamino, (2-4C)alkanoyloxyamino, trifluoromethoxy, (1-4C)alkyl, (1-4C)alkoxy and (1-3C)alkylenedioxy; n is 1 or 2 and each R.sup.2 includes hydrogen, hydroxy, halogeno, trifluoromethyl, amino, nitro, cyano and (1-4C)alkyl; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cancer.|
|Inventor(s):|| Barker; Andrew J. (Macclesfield, GB2) |
|Assignee:|| Zeneca Limited (London, GB) |
Patent Claim Types:|
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Foreign Priority and PCT Information for Patent: 5,616,582
|Foriegn Application Priority Data|
||Foreign Patent Number
||Foreign Patent Date
|United Kingdom||9201095||Jan 20, 1992|
|United Kingdom||9213572||Jun 26, 1992|
|United Kingdom||9223735||Nov 12, 1992|
International Patent Family for Patent: 5,616,582
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