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Serving hundreds of leading biopharmaceutical companies globally:

Teva
Argus Health
Moodys
QuintilesIMS
Deloitte
Chubb
Healthtrust
Farmers Insurance
Express Scripts

Generated: June 24, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,616,334

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Summary for Patent: 5,616,334
Title: Low toxicity drug-lipid systems
Abstract:Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
Inventor(s): Janoff; Andrew S. (Yardley, PA), Boni; Lawrence (Monmouth Junction, NJ), Madden; Thomas D. (Vancouver, CA), Cullis; Pieter R. (Vancouver, CA), Lenk; Robert P. (Lambertville, NJ), Kearns; John J. (Princeton, NJ), Durning; Anthony G. (Yardley, PA), Klimchak; Robert (Flemington, NJ), Portnoff; Joel (Richboro, PA)
Assignee: The Liposome Company, Inc. (Princeton, NJ)
Application Number:08/430,699
Patent Claim Types:
see list of patent claims
Composition; Dosage form; Use;

Drugs Protected by US Patent 5,616,334

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Family Members for US Patent 5,616,334

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 113468 ➤ Try a Free Trial
Austria 118169 ➤ Try a Free Trial
Australia 1799088 ➤ Try a Free Trial
Australia 622405 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Cerilliant
Dow
Johnson and Johnson
Express Scripts
US Department of Justice
Argus Health
McKesson
Deloitte
Chubb

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