Generated: December 13, 2017
DrugPatentWatch Database Preview
Details for Patent: 5,614,560
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Summary for Patent: 5,614,560
|Title:|| Method of preventing NMDA receptor-mediated neuronal damage|
|Abstract:||Disclosed is a method for reducing non-ischemic NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a compound of the formula shown in FIG. 1 (or a physiologically-acceptable salt thereof), wherein R.sub.1 includes an amino group, R.sub.2 -R.sub.17 are independently H or a short chain aliphatic group comprising 1-5 carbons, and R.sub.4 and R.sub.10 also may (independently) be a halogen or an acyl group. Also disclosed is a screen for antagonists of NMDA receptor mediated neurotoxicity which have an enhanced prospect for being clinically tolerated and selective against such neurotoxicity.|
|Inventor(s):|| Lipton; Stuart A. (Newton, MA) |
|Assignee:|| Children's Medical Center Corporation (Boston, MA) |
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International Patent Family for Patent: 5,614,560
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