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Generated: August 23, 2017

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Title: Pharmaceutical excipient having improved compressability
Abstract:A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.
Inventor(s): Sherwood; Bob E. (Amenia, NY), Hunter; Edward A. (Glenham, NY), Staniforth; John H. (Bath, GB2)
Assignee: Edward H. Mendell Co., Inc. (Patterson, NY)
Application Number:08/370,576
Patent Claim Types:
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Composition;

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Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia5830399► Subscribe
Brazil9605245► Subscribe
Brazil9605329► Subscribe
Canada2183881► Subscribe
Canada2183882► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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