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Serving hundreds of leading biopharmaceutical companies globally:

Merck
Boehringer Ingelheim
McKesson
Healthtrust
Teva
Harvard Business School
Baxter
Argus Health
US Department of Justice

Generated: April 25, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,578,621

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Summary for Patent: 5,578,621
Title: Benzamide derivatives
Abstract:The present invention relates to a new compound of formula I ##STR1## with one of the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 representing OH, whereas the remaining symbols represent H; to a pharmaceutical composition containing the said compound, and to the use of said compound as anti-parasital, anti-bacterial, anti-fungal agent. The Prior Art Nitrothiazole compound PH 5776 (2-(acetolyloxy)-N-(5-nitro 2-thiazolyl) benzamide) is a compound of formula II ##STR2## in which R.sub.1 =O--COCH3 R.sub.2 =R.sub.3 =R.sub.4 =R.sub.5 =H The preparation and uses of this compound are disclosed in U.S. Pat. No. 3,950,351, as well as in publication made by Applicant. In U.S. Pat. No. 3,950,351, the compound of formula II is prepared by reacting ##STR3## This reaction is not suitable for the preparation of pure compound of formula I ##STR4## in which one of the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent OH, whereas the remaining symbols represent H. Moreover, contrary to what could be expected from the prior art, i.e. that the presence of an acyloxy group was necessary for rendering the compound active and efficient against bacteria, parasites, . . . , it has now been found that the compound of formula I ##STR5## with one of the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 representing OH, whereas the remaining symbols represent H; had an excellent efficiency against parasites, bacteria, fungus although it does not contain an acyloxy group. The compound of formula I had a substantially immediate action against parasite, fungus, bacteria.
Inventor(s): Rossignol; Jean-Francois (Clearwater, FL)
Assignee:
Application Number:08/301,407
Patent Claim Types:
see list of patent claims
Composition; Compound; Use;

Drugs Protected by US Patent 5,578,621

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,578,621

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Hong Kong 1025907 ➤ Try a Free Trial
Canada 2182228 ➤ Try a Free Trial
Canada 2187110 ➤ Try a Free Trial
Canada 2288003 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

McKesson
Farmers Insurance
AstraZeneca
Julphar
Chinese Patent Office
Fuji
Argus Health
Baxter
Johnson and Johnson

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