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Details for Patent: 5,545,644

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Patent 5,545,644 protects RELPAX and is included in one NDA. There has been one Paragraph IV challenge on Relpax. There are four tentative approvals for the compound protected by this patent. Additional details are available via the generic ingredient links below.

This patent has ninety-four patent family members in thirty-six countries.

Summary for Patent: 5,545,644

Title: Indole derivatives
Abstract:Compounds of the formula ##STR1## wherein n is 0, 1, or 2; X is hydrogen, chlorine, bromine or iodine; R.sub.1 is hydrogen; R.sub.3 is selected from hydrogen and C.sub.1 to C.sub.6 linear or branched alkyl; and R.sub.2 is as defined in the specification and the pharmaceutically acceptable salts thereof are useful psychotherapeutics and are potent serotonin (5-HT.sub.1) agonists and may be used in the treatment of depression, anxiety, eating disorders, obesity, drug abuse, cluster headache, migraine, pain, chronic paroxysmal hemicrania and headache associated with vascular disorders, and other disorders arising from deficient serotonergic neurotransmission. The compounds can also be used as centrally acting antihypertensives and vasodilators. A process for forming indoles by transition metal catalyzed cyclization of a dihalogenated intermediate is also disclosed.
Inventor(s): Macor; John E. (New York, NY), Wythes; Martin J. (New York, NY)
Assignee: Pfizer Inc. (New York, NY)
Application Number:08/466,644
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Pfizer Ireland
RELPAX
eletriptan hydrobromide
TABLET;ORAL021016-001Dec 26, 2002RXNo5,545,644► subscribeYY TREATMENT OF MIGRAINE WITH OR WITHOUT AURA
Pfizer Ireland
RELPAX
eletriptan hydrobromide
TABLET;ORAL021016-002Dec 26, 2002RXYes5,545,644► subscribeYY TREATMENT OF MIGRAINE WITH OR WITHOUT AURA
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Non-Orange Book Patents for Patent: 5,545,644

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
5,607,951 Indole derivatives► subscribe
5,559,129 Indole derivatives► subscribe
5,559,246 Indole derivatives► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 5,545,644

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
African Regional IP Organization (ARIPO)486► subscribe
African Regional IP Organization (ARIPO)9400633► subscribe
Austria157361► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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