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|Title:||Orally administrable pharmaceutical compositions|
|Abstract:||A solid dosage form, such as a capsule or tablet, containing a pharmacologically active agent is coated with an anionic polymer, which is insoluble in gastric juice and in intestinal juice below pH7 but soluble in colonic intestinal juice, in a sufficient amount that the oral dosage form remains intact until it reaches the colon. The preferred anionic polymer is a partly methyl esterified methacrylic acid polymer in which the ratio of free carboxylic groups to ester groups is about 1:2. The invention has particular application to dosage forms of prednisolone and salts thereof, indomethacin, ibuprofen, and, especially, 5-amino-salicylic acid.|
|Inventor(s):||Rhodes; John (Cardiff, GB7), Evans; Brian K. (Dinas Powis, GB7)|
|Assignee:||Tillotts Pharma AG (Ziefen, CH)|
Patent Claim Types:|
see list of patent claims
|Use; Composition; Compound; Dosage form;|
|Foriegn Application Priority Data|
|Foreign Country||Foreign Patent Number||Foreign Patent Date|
|United Kingdom||8123573||Jul 31, 1981|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|Canada||1172570||<disabled in preview>|
|Denmark||128283||<disabled in preview>|
|Denmark||158931||<disabled in preview>|
| This preview shows a limited data set|
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.
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