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Serving hundreds of leading biopharmaceutical companies globally:

Johnson and Johnson
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US Department of Justice
Healthtrust
Covington
Citi
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Generated: July 22, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,472,949

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Summary for Patent: 5,472,949
Title: N.sup.4 -(substituted-oxycarbonyl)-5'-deoxy-5-fluorocytidine compounds, compositions and methods of using same
Abstract:The invention relates to N.sup.4 -(substituted-oxycarbonyl)-5'-deoxy-5-fluorocytidine derivatives which are useful as an agent for treating tumors, pharmaceutical compositions including the same, a method of treating tumors and a method of preparing N.sup.4 -(substituted-oxycarbonyl)-5'-deoxy-5-fluorocytidine derivatives for treating tumors. Compounds of formula (I), ##STR1## wherein R.sup.1 is a saturated or unsaturated, straight or branched hydrocarbon radical wherein the number of carbon atoms in the longest straight chain of this hydrocarbon radical ranges from three to seven, or is a radical of the formula --(CH.sub.2)n--.sup.Y wherein Y is a cyclohexyl radical, a C.sub.1 -C.sub.4 alkoxy radical or a phenyl radical and wherein when Y is a cyclohexyl radical n is an integer from 0 to 4, and when Y is C.sub.1 -C.sub.4 alkoxy radical or a phenyl radical n is an integer from 2 to 4, and R.sup.2 is a hydrogen atom or a radical easily hydrolyzable under physiological conditions, or a hydrate or solvate thereof. Compounds of formula (I) are useful in the treatment of tumors.
Inventor(s): Arasaki; Motohiro (Kanagawa, JP), Ishitsuka; Hideo (Kanagawa, JP), Kuruma; Isami (Kanagawa, JP), Miwa; Masanori (Kanagawa, JP), Murasaki; Chikako (Kanagawa, JP), Shimma; Nobuo (Kanagawa, JP), Umeda; Isao (Kanagawa, JP)
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Application Number:08/167,392
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 5,472,949
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 5,472,949

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate

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Foreign Priority and PCT Information for Patent: 5,472,949

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
92121538Dec 18, 1992

International Family Members for US Patent 5,472,949

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Hungary T65757 ➤ Try a Free Trial
Hungary 9303525 ➤ Try a Free Trial
Croatia P931430 ➤ Try a Free Trial
Hong Kong 1005875 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

QuintilesIMS
Mallinckrodt
Harvard Business School
Dow
Argus Health
Accenture
Baxter
Express Scripts
Chinese Patent Office

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