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Serving leading biopharmaceutical companies globally:

Julphar
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Fish and Richardson
QuintilesIMS
Chinese Patent Office
Covington
McKesson
Medtronic
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Cipla

Generated: January 23, 2018

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Details for Patent: 5,462,745

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Summary for Patent: 5,462,745
Title: Subsaturated transdermal therapeutic system having improved release characteristics
Abstract:Rate controlled transdermal delivery devices are disclosed which utilize an in-line adhesive to maintain the device on the skin and deliver an agent which is a solvent or a plasticizer for the in-line adhesive. The initial equilibrated concentration of the agent in the agent reservoir and the adhesive is below saturation, and the reservoir comprises the agent dissolved in a solvent with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of the agent in reservoir is sufficient to prevent the activity of the agent in the reservoir from decreasing by more than about 50% and preferably no more than about 25% during the predetermined period of administration: and the thicknesses of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and preferably at least 75% initial equilibrated agent loading is in the reservoir layer. The devices are usable to deliver agents which are liquid at body temperatures such as benztropine, secoverine, nicotine, arecoline, polyethylene glycol monolaurate, glycerol monolaurate, glycerol monooleate and ethanol, for example.
Inventor(s): Enscore; David J. (Sunnyvale, CA), Campbell; Patricia S. (Palo Alto, CA), Osborne; James L. (Mountain View, CA), Smart; Melinda K. (Sunnyvale, CA), Yum; Su I. (Los Altos, CA)
Assignee: Alza Corporation (Palo Alto, CA)
Application Number:08/297,739
Patent Claim Types:
see list of patent claims
Delivery; Device; Use;

Drugs Protected by US Patent 5,462,745

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,462,745

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 161734 ➤ Subscribe
Australia 3852189 ➤ Subscribe
Australia 3913695 ➤ Subscribe
Australia 4491193 ➤ Subscribe
Australia 630614 ➤ Subscribe
Australia 666208 ➤ Subscribe
Australia 682813 ➤ Subscribe
Australia 684394 ➤ Subscribe
Australia 8585291 ➤ Subscribe
Canada 1338700 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Accenture
Farmers Insurance
Baxter
Colorcon
Queensland Health
Cantor Fitzgerald
Fish and Richardson
Mallinckrodt
Daiichi Sankyo

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