The present invention relates to active substance plasters for the controlled release of active substances to the skin consisting of a backing layer, an adhesive film connected therewith which film is water-soluble and consists of pressure-sensitive adhesive which comprises water-swellable polymers and in which the active substance is at least partially soluble, and of a removable protective layer covering the adhesive film, in which plasters the pressure-sensitive adhesive is based on homo and/or copolymers with at least one derivative of the acrylic or methacrylic acid, and which comprise as active substances, partially or completely dissolved in the adhesive, at a concentration of 0.5 to 10.0%-wt estrogens and their pharmaceutically acceptable derivatives alone or in combination with gestagens.
Hoffmann; Hans-Rainer (Neuwied, DE), Klein; Robert P. (Neuwied, DE), Meconi; Reinhold (Neuwied, DE), Cordes; Gunter (Leichingen, DE), Wolff; Hans M. (Monheim, DE)
LTS Lohmann Therapie-Systeme GmbH & Co. KG (Neuweid, DE) Schwarz Pharma AG (Monheim, DE)
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