Details for Patent: 5,279,811
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Summary for Patent: 5,279,811
Title: | Ester-substituted diaminedithiols and radiolabeled complexes thereof |
Abstract: | Radiopharmaceuticals consisting essentially of a lipophilic, charge neutral radionuclide complex of a diaminedithiol ligand having 1-4 ester groups of the formula --A--COOR where A is a straight or branched chain alkylene of 0-10 carbon atoms and R is an alkyl group of 1-10 carbon atoms are useful in radioimaging brain perfusion in primates. Ester-substituted diaminedithiols in sterile, pharmaceutically acceptable form, and kits of the diaminedithiols and sterile, non-pyrogenic reducing agents for reducing preselected radionuclides are also provided. Technetium-99m is a preferred radionuclide. |
Inventor(s): | Bergstein; Paul L. (Norwood, MA), Cheesman; Edward H. (Townsend, MA), Watson; Alan D. (Andover, MA) |
Assignee: | The Du Pont Merck Pharmaceutical Company (Wilmington, DE) |
Application Number: | 07/143,561 |
Patent Claim Types: see list of patent claims | Compound; Composition; Process; |
Drugs Protected by US Patent 5,279,811
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International Family Members for US Patent 5,279,811
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Germany | 19475010 | ⤷ Try a Trial | |||
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