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Serving hundreds of leading biopharmaceutical companies globally:

Cipla
Boehringer Ingelheim
Cerilliant
Argus Health
Fish and Richardson
Johnson and Johnson
Citi
US Department of Justice
Julphar

Generated: April 24, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,236,952

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Summary for Patent: 5,236,952
Title: Catechol derivatives
Abstract:Catechol derivatives of the formula ##STR1## wherein Ra, Rb and Rc have the significance given herein, the ester and ether derivatives thereof which are hydrolyzable under physiological conditions and the pharmaceutically acceptable salts thereof are described and possess valuable pharmacological properties. In particular, they inhibit the enzyme catechol-O-methyltransferase (COMT), a soluble, magnesium-dependent enzyme which catalyses the transference of the methyl group of S-adensoylmethionine to a catechol substrate, whereby the corresponding methyl ethers are formed. Suitable substrates which can be O-methylated by COMT and which can thus be deactivated are, for example, extraneuornal catecholamines and exogeneously-administered therapeutically active substances having a catechol structure. Formula Ia above embraces not only compounds which form part of the invention, but also known compounds; the compounds which form part of the invention can be prepared according to known methods.
Inventor(s): Bernauer; Karl (Oberwil, CH), Borgulya; Janos (Basel, CH), Bruderer; Hans (Biel-Benken, CH), DaPrada; Mose (Riehen, CH), Zurcher; Gerhard (Basel, CH)
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Application Number:07/686,210
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 5,236,952

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 5,236,952

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Switzerland980/86Mar 11, 1986
Switzerland62/87Jan 09, 1987

International Patents Family Members for US Patent 5,236,952

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Spain 2056792 ➤ Sign Up
European Patent Office 0237929 ➤ Sign Up SPC/GB97/088 United Kingdom ➤ Sign Up
European Patent Office 0237929 ➤ Sign Up 97C0112 Belgium ➤ Sign Up
European Patent Office 0237929 ➤ Sign Up C970041 Netherlands ➤ Sign Up
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Express Scripts
Queensland Health
Baxter
Chinese Patent Office
McKinsey
Moodys
US Army
Colorcon
Citi

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