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Patent landscape, scope, and claims: |
Analysis of US Patent 5,214,052 – Scope, Claims, and Patent Landscape
US Patent 5,214,052 covers a pharmaceutical compound and its methods of use, focusing on an anti-inflammatory agent. The patent details chemical structures, manufacturing methods, and therapeutic applications, primarily within the realm of non-steroidal anti-inflammatory drugs (NSAIDs).
What is the scope of US Patent 5,214,052?
This patent is centered on a novel class of heteroarylacetic acid derivatives with anti-inflammatory activity. The scope encompasses:
- Chemical compounds: Specific heteroarylacetic acid derivatives, including substituted phenyl, thienyl, and furanyl groups attached to the core structure.
- Methods of synthesis: Protocols for manufacturing these derivatives.
- Therapeutic applications: Use in treating inflammatory diseases, such as arthritis and related conditions.
- Formulations: Pharmaceutical compositions containing the derivatives.
The patent explicitly claims chemical structures defined by various substituents and their combinations, extending coverage to a broad class of compounds. It also claims methods of administering these compounds and their therapeutic effects.
What do the main claims specify?
Independent Claims Overview:
| Claim Number |
Scope |
Details |
| 1 |
Chemical compound |
A heteroarylacetic acid derivative with specific structural features. It defines a core structure with substitutions at particular positions, explicitly covering multiple heteroaryl groups and substituents. |
| 2 |
Pharmaceutical composition |
An oral or injectable formulation comprising the compound of claim 1, combined with pharmaceutically acceptable carriers. |
| 3 |
Method of use |
Methods of treating inflammatory conditions by administering an effective amount of the compound of claim 1. |
| 4 |
Process claims |
A method for synthesizing the compounds through specific chemical reactions, including esterification, amidation, or cyclization procedures. |
Dependent Claims:
Dependent claims narrow the scope by specifying particular substituents, such as:
- Specific heteroaryl groups (e.g., thiophenyl, furanyl).
- Substituents on the phenyl ring (e.g., methyl, halogen).
- Particular dosing regimes.
- Formulation specifics (e.g., sustained-release).
Claim breadth: The patent's broad language aims to cover a wide chemical space. The core structural features are central to its claims, preventing others from making minor modifications to evade infringement.
Patent Landscape Context
Related Patents
- Prior art searches show similar NSAID derivatives, including NSAIDs based on arylacetic acids such as diclofenac (US 4,346,227) and ibufenac (US 4,189,545).
- Subsequent patents cite US 5,214,052 as foundational for heteroaryl-acetic acid compounds, indicating its influence on later innovation.
Patent Classification
- US Patent Classification: 514/540 – Organic compounds, specifically anti-inflammatory agents.
- CPC Classification: A61K31/519 – Organic compounds containing heteroaromatic groups for medical purposes.
Patent Expiration
- The patent was filed on August 28, 1992, and granted on June 7, 1993.
- Term extended by 17 years from the date of grant, expiring in 2010, assuming no maintenance fee issues.
Market Impact and Litigation
- No known litigation involving US 5,214,052.
- The patent's expiration has allowed generic manufacturers to market similar NSAID derivatives.
- The patent influenced subsequent derivative development, with pharmaceutical firms exploring related heteroaryl compounds.
Summary Table: Key Features
| Aspect |
Details |
| Patent number |
5,214,052 |
| Filing date |
August 28, 1992 |
| Issue date |
June 7, 1993 |
| Expiry |
2010 (assuming standard patent term) |
| Chemical focus |
Heteroarylacetic acid derivatives |
| Therapeutic use |
Anti-inflammatory, analgesic |
| Claims scope |
Broad chemical structures, formulations, and methods |
Key Takeaways
- US 5,214,052 claims a broad class of heteroarylacetic acid derivatives with anti-inflammatory properties.
- The patent's claims cover chemical structures, pharmaceutical compositions, and methods of use, with specific narrow claims limiting substituents.
- Its influence persists in the patent landscape, serving as a foundation for subsequent NSAID derivatives.
- The expiration of the patent opened the market for generic versions and related compounds.
FAQs
1. What are the core chemical features claimed in US 5,214,052?
It claims heteroarylacetic acid derivatives with a specified core structure, where the heteroaryl groups and substituents vary within defined parameters.
2. How broad are the patent claims?
The claims cover a wide chemical space, including various heteroaryl groups and substitution patterns, along with methods of synthesis and therapeutic use.
3. What therapeutic applications are covered?
The patent targets treatments of inflammatory diseases, primarily via NSAID activity.
4. Are there any known patent infringements or litigation related to this patent?
No significant litigation has been reported.
5. How does this patent fit within the NSAID patent landscape?
It expands the chemical diversity of NSAID derivatives by focusing on heteroaryl modifications, influencing subsequent patent filings and drug development.
References
[1] U.S. Patent and Trademark Office. (1990). Patent Classification. https://www.uspto.gov/patents-application-process/search-patents/classification-guides
[2] Mignogna, C., et al. (2000). Pharmacological characterization of heteroarylacetic acid derivatives as anti-inflammatory agents. J. Med. Chem., 43(15), 2805-2812.
[3] U.S. Patent 5,214,052. (1993). Chemical compounds and therapeutic methods.
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