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Generated: December 18, 2017

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Details for Patent: 5,206,248

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Summary for Patent: 5,206,248

Title: Method for reducing emotional lability
Abstract:This invention discloses that certain types of non-addictive opioid drugs such as dextromethorphan (which is widely used in cough syrups) provide a highly effective means of treating the feelings and symptoms of emotional lability in at least some patients suffering from neurologic impairment, without sedating, tranquilizing, or otherwise significantly interfering with consciousness or alertness in the patient. In several patients tested to date who were suffering from amyotrophic lateral sclerosis (ALS), dextromethorphan, administered orally, was remarkably effective and became quite obvious to the patients even though it was being tested for an entirely different purpose. Its effectiveness is enhanced by co-administration of a second drug such as quinidine which reduces the degradation of dextromethorphan by oxidative enzymes and which therefore increases dextromethorphan concentrations in the blood.
Inventor(s): Smith; Richard A. (La Jolla, CA)
Application Number:07/859,105
Patent Claim Types:
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Use; Dosage form;

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International Patent Family for Patent: 5,206,248

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Canada2114267► Subscribe
Canada2712821► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
Queensland Health
US Department of Justice
Johnson and Johnson

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