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Generated: October 20, 2017

DrugPatentWatch Database Preview

Details for Patent: 5,198,533

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Summary for Patent: 5,198,533

Title: LHRH antagonists
Abstract:The present invention deals with LHRH antagonists which possess improved water solubility and while having the high antagonist potency of the basic peptides, are free of the edematogenic effects. These compounds are highly potent in inhibiting the release of gonadotropins from the pituitary gland in mammals, including humans. The compounds of this invention are represented by the formula wherein X is an acyl group derived from straight or branched chain aliphatic or alicyclic carboxylic acids having from 1 to 7 carbon atoms, or H.sub.2 N--CO, R.sup.1 is D-- or L--Pro, D-- or L--.DELTA..sup.3 --Pro, D--Phe, D--Phe(4--H1), D--Ser, D--Thr, D--Ala, D--Nal(1) or D--Nal (2), R.sup.2 is D--Phe or D--Phe(4--C1) R.sup.3 is D--Trp, D--Phe, D--Pal(3), D--Nal(1) or D--Nal(2), R.sup.6 is D--Cit, D--Hci, D--Cit(Q) or D--Hci(Q) and R.sup.10 is Gly or D--Ala where Q is lower alkyl of 1-3 carbon atoms and H1 is fluoro, chloro or bromo, and the pharmaceutically acceptable acid addition salts thereof and methods of use pertaining to these compounds.
Inventor(s): Schally; Andrew V. (Metarie, LA), Bajusz; Sandor (New Orleans, LA)
Assignee: The Administrators of the Tulane Educational Fund (New Orleans, LA)
Application Number:07/197,153
Patent Claim Types:
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Compound;

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International Patent Family for Patent: 5,198,533

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Denmark395688► Subscribe
Denmark173375► Subscribe
European Patent Office0299402► SubscribeC990029Netherlands► Subscribe
European Patent Office0299402► Subscribe099C0031Belgium► Subscribe
European Patent Office0299402► Subscribe31/1999Austria► Subscribe
Spain2054741► Subscribe
Finland883388► Subscribe
Finland91075► Subscribe
Finland933629► Subscribe
Germany19975052► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Argus Health
US Department of Justice
Accenture
Moodys
Cipla
Colorcon
Fuji
Harvard Business School
Boehringer Ingelheim
Teva

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