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Serving leading biopharmaceutical companies globally:

McKinsey
Medtronic
Colorcon
AstraZeneca
Fuji
Cerilliant
Citi
Novartis
Chubb
Express Scripts

Generated: January 16, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,192,535

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Summary for Patent: 5,192,535
Title: Ophthalmic suspensions
Abstract:Lightly crosslinked polymers, preferably ones prepared by suspension or emulsion polymerizing at least about 90% by weight of a carboxyl-containing monoethylenically unsaturated monomer such as acrylic acid with from about 0.1% to about 5% by weight of a polyfunctional, and preferably difunctional, crosslinking agent such as divinyl glycol (3,4-dihydroxy-1,5-hexadiene), having a particle size of not more than about 50 .mu.m in equivalent spherical diameter, when formulated with an ophthalmic medicament, e.g., fluorometholone, into suspensions in aqueous medium in which the amount of polymer ranges from about 0.1% to about 6.5% by weight, based on the total weight of the aqueous suspension, the pH is from about 3.0 to about 6.5, and the osmotic pressure (osmolality or tonicity) is from about 10 mOsM to about 400 mOsM, provide new topical ophthalmic medicament delivery systems having suitably low viscosities which permit them to be easily administered to the eye in drop form, and hence be comfortably administrable in consistent, accurate dosages. These suspension will rapidly gel in the eye after coming into contact with the eye's tear fluid to a substantially greater viscosity than that of the originally-introduced suspension and thus remain in place for prolonged periods of time to provide sustained release of the ophthalmic medicament.
Inventor(s): Davis; Jeffrey P. (Madison, WI), Chandrasekaran; Santosh K. (Moraga, CA), Su; Yansheng (Shandong, CN), Archibald; Roy D. (Fremont, CA), Robinson; Joseph R. (Madison, WI)
Assignee: InSite Vision Incorporated (Alameda, CA)
Application Number:07/544,518
Patent Claim Types:
see list of patent claims
Delivery; Use;

Drugs Protected by US Patent 5,192,535

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,192,535

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 243728 ➤ Subscribe
Austria 112157 ➤ Subscribe
Austria 113841 ➤ Subscribe
Austria 152907 ➤ Subscribe
Austria 178476 ➤ Subscribe
Austria 181824 ➤ Subscribe
Austria 91408 ➤ Subscribe
Australia 639069 ➤ Subscribe
Australia 7033191 ➤ Subscribe
Australia 8103991 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Accenture
Cerilliant
Daiichi Sankyo
Chinese Patent Office
UBS
Cipla
Medtronic
Boehringer Ingelheim
Moodys

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