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Serving leading biopharmaceutical companies globally:

Cantor Fitzgerald
Boehringer Ingelheim
US Army

Generated: November 17, 2017

DrugPatentWatch Database Preview

Details for Patent: 5,192,535

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Summary for Patent: 5,192,535

Title: Ophthalmic suspensions
Abstract:Lightly crosslinked polymers, preferably ones prepared by suspension or emulsion polymerizing at least about 90% by weight of a carboxyl-containing monoethylenically unsaturated monomer such as acrylic acid with from about 0.1% to about 5% by weight of a polyfunctional, and preferably difunctional, crosslinking agent such as divinyl glycol (3,4-dihydroxy-1,5-hexadiene), having a particle size of not more than about 50 .mu.m in equivalent spherical diameter, when formulated with an ophthalmic medicament, e.g., fluorometholone, into suspensions in aqueous medium in which the amount of polymer ranges from about 0.1% to about 6.5% by weight, based on the total weight of the aqueous suspension, the pH is from about 3.0 to about 6.5, and the osmotic pressure (osmolality or tonicity) is from about 10 mOsM to about 400 mOsM, provide new topical ophthalmic medicament delivery systems having suitably low viscosities which permit them to be easily administered to the eye in drop form, and hence be comfortably administrable in consistent, accurate dosages. These suspension will rapidly gel in the eye after coming into contact with the eye's tear fluid to a substantially greater viscosity than that of the originally-introduced suspension and thus remain in place for prolonged periods of time to provide sustained release of the ophthalmic medicament.
Inventor(s): Davis; Jeffrey P. (Madison, WI), Chandrasekaran; Santosh K. (Moraga, CA), Su; Yansheng (Shandong, CN), Archibald; Roy D. (Fremont, CA), Robinson; Joseph R. (Madison, WI)
Assignee: InSite Vision Incorporated (Alameda, CA)
Application Number:07/544,518
Patent Claim Types:
see list of patent claims
Delivery; Use;

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International Patent Family for Patent: 5,192,535

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Denmark167344► Subscribe
Denmark493689► Subscribe
Germany69012955► Subscribe
Germany69014081► Subscribe
Germany69033199► Subscribe
Germany69126134► Subscribe
Germany69131100► Subscribe
Denmark47793► Subscribe
Denmark168727► Subscribe
Denmark0429156► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Federal Trade Commission
Fish and Richardson
Johnson and Johnson
Chinese Patent Office

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