Sulphated glycosaminoglycuronan with antithrombotic activity
The present invention relates to sulphated glycosamino glycuronan with antithrombotic activity consisting essentially of salts of dermatan sulphate, chondroitin sulphate and heparan sulphate, characterized by a) an average molecular weight between 4000 and 8000 daltons; b) a nitrogen content between 2.4 and 3.0%; c) a sulphur content between 7.5 and 9.5%; d) a sodium content between 9 and 11%; e) a dermatan sulphate content between 5 and 25%; f) a chondroitin sulphate content less than 9%; g) an anti-Xa activity between 11 and 20 .mu./mg; and h) an antithrombin III dependent antithrombin activity of less than 1 .mu./mg.
Van Dedem; Gijsbert W. K. (Oss, NL), Van Hou Denhoven; Francois E. A. (Heesch, NL), Meuleman; Dirk G. (Oss, NL), Moelker; Huibert C. T. (Megen, NL), Sanders; Adrianus L. M. (Uden, NL)
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