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Last Updated: August 8, 2020

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Details for Patent: 5,142,051

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Summary for Patent: 5,142,051
Title: N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases and a therapeutical composition therefrom with antiviral activity
Abstract:This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from heterocyclic bases andd their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds, according to this invention, exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.
Inventor(s): Holy; Antonin (Horni Pocernice, CS), Rosenberg; Ivan (Praha, CS), De Clercq; Erik D. A. (Leuven, BE)
Assignee: Ceskoslovenska Akademie Ved (Praha, CS) Rega Institut (Leuven, BE)
Application Number:07/074,900
Patent Claim Types:
see list of patent claims

Drugs Protected by US Patent 5,142,051

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 5,142,051

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Czechoslovakia5469-86Jul 18, 1986

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