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Generated: December 17, 2017

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Details for Patent: 5,142,051

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Summary for Patent: 5,142,051

Title: N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases and a therapeutical composition therefrom with antiviral activity
Abstract:This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from heterocyclic bases andd their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds, according to this invention, exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.
Inventor(s): Holy; Antonin (Horni Pocernice, CS), Rosenberg; Ivan (Praha, CS), De Clercq; Erik D. A. (Leuven, BE)
Assignee: Ceskoslovenska Akademie Ved (Praha, CS) Rega Institut (Leuven, BE)
Application Number:07/074,900
Patent Claim Types:
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Foreign Priority and PCT Information for Patent: 5,142,051

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Czechoslovakia5469-86Jul 18, 1986

International Patent Family for Patent: 5,142,051

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Czechoslovakia8605469► Subscribe
Spain2036194► Subscribe
European Patent Office0253412► SubscribeSPC/GB97/083United Kingdom► Subscribe
European Patent Office0253412► Subscribe97C0105Belgium► Subscribe
European Patent Office0253412► SubscribeC970036Netherlands► Subscribe
European Patent Office0253412► Subscribe63/1997Austria► Subscribe
Egypt18273► Subscribe
Denmark170646► Subscribe
Denmark373487► Subscribe
Germany19775085► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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