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Last Updated: August 8, 2020

DrugPatentWatch Database Preview

Details for Patent: 5,142,051

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Summary for Patent: 5,142,051
Title: N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases and a therapeutical composition therefrom with antiviral activity
Abstract:This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from heterocyclic bases andd their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds, according to this invention, exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.
Inventor(s): Holy; Antonin (Horni Pocernice, CS), Rosenberg; Ivan (Praha, CS), De Clercq; Erik D. A. (Leuven, BE)
Assignee: Ceskoslovenska Akademie Ved (Praha, CS) Rega Institut (Leuven, BE)
Application Number:07/074,900
Patent Claim Types:
see list of patent claims
Compound;

Drugs Protected by US Patent 5,142,051

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 5,142,051

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Czechoslovakia5469-86Jul 18, 1986

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