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Serving hundreds of leading biopharmaceutical companies globally:

Teva
Cerilliant
Medtronic
McKesson
Colorcon
Harvard Business School
Mallinckrodt
Argus Health
Boehringer Ingelheim

Generated: April 27, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,071,643

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Summary for Patent: 5,071,643
Title: Solvent system enhancing the solubility of pharmaceuticals for encapsulation
Abstract:This invention relates to a solvent system for enhancing the solubility of an acidic, basic, or amphoteric pharmaceutical agent to produce a highly concentrated solution suitable for softgel filling or two piece encapsulation. The solvent system comprises polyethylene glycol containing 0.2-1.0 mole equivalents of an ionizing agent per mole equivalent pharmaceutical agent and 1-20% water. Glycerin or polyvinylpyrrolidone may be added to further enhance the solubility of certain drugs. The disclosed solvent system is capable of enhancing solubilities of pharmaceutical agents 40-400%. The ionizing agent functions by causing partial ionization (neutralization) of the free pharmaceutical agent. When the pharmaceutical agent is acidic, the ionizing agent is preferably a hydroxide ion species, whereas when the pharmaceutical agent is basic, the ionizing agent is preferably a hydrogen ion species. For amphoteric pharmaceutical agents, either hydroxide ion or hydrogen ion sources may be utilized to effect partial ionization. The disclosed solvent system is useful because it not only provides for the enhancement or improvement of bioavailability of acidic, basic and amphoteric pharmaceutical agents by delivering them already in solution, but it also provides for a highly concentrated solution capable of encapsulation in a small enough vessel to permit easy swallowing. The highly concentrated solid solutions of the present invention are also useful for conversion into tablets and as veterinary spot and pour on preparations.
Inventor(s): Yu; Man S. (Rochester, NY), Hom; Foo S. (Safety Harbor, FL), Chakrabarti; Sibaprasanna (Oldsmer, FL), Huang; Chong-Heng (Madison, NJ), Patel; Mahendra (Swindon, GB2)
Assignee: R. P. Scherer Corporation (Troy, MI)
Application Number:07/104,911
Patent Claim Types:
see list of patent claims
Formulation; Compound; Dosage form;

Drugs Protected by US Patent 5,071,643

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Family Members for US Patent 5,071,643

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 66810 ➤ Try a Free Trial
Australia 8157387 ➤ Try a Free Trial
Australia 606367 ➤ Try a Free Trial
Canada 1316823 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Colorcon
US Army
Chinese Patent Office
McKinsey
AstraZeneca
Boehringer Ingelheim
Farmers Insurance
Daiichi Sankyo
US Department of Justice

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