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Serving leading biopharmaceutical companies globally:

Queensland Health
US Department of Justice
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Express Scripts
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Generated: December 15, 2017

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Details for Patent: 5,055,288

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Summary for Patent: 5,055,288

Title: Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides
Abstract:The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable superparamagnetic metal oxide crystals which aggregates have an overall mean diameter less than about 4000 angstroms. The preferred vascular imaging contrast agent is comprised of aggregates of iron oxide crystals having an overall mean diameter less than about 500 angstroms. These contrast agents may be associated with a macromolecular species, which assist, among other things, in the preparation of these extremely small materials, and may be dispersed or dissolved in a physiologically acceptable medium. Preferred media also stabilize the materials against further aggregation even under harsh sterilization conditions. The autoclaved biodegradable superparamagnetic iron oxides of the invention are ideally suited for a pharmaceutical preparation and enjoy several advantages over prior intravascular imaging contrast media including low osmolality, low effective dose requirements, high relaxivities, long blood lifetimes, rapid biodegradability, and versatility with respect to a wide range of applicable MR data acquisition parameters.
Inventor(s): Lewis; Jerome M. (Newton, MA), Menz; Edward T. (Quincy, MA), Kenny; Francis E. (Watertown, MA), Groman; Ernest V. (Brookline, MA), Josephson; Lee (Arlington, MA)
Assignee: Advanced Magnetics, Inc. (Cambridge, MA)
Application Number:07/233,177
Patent Claim Types:
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Formulation; Composition;

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International Patent Family for Patent: 5,055,288

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria135920► Subscribe
Austria139431► Subscribe
Austria142891► Subscribe
Austria143604► Subscribe
Austria143814► Subscribe
Austria151991► Subscribe
Australia2545292► Subscribe
Australia2700195► Subscribe
Canada1301063► Subscribe
Canada2075491► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Queensland Health
Federal Trade Commission
Cantor Fitzgerald
Harvard Business School
US Army

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